Positive regulation of extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of extracellular matrix assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLASP1, TGFB1, and SRPK2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLASP1 grouped by Positive regulation of extracellular matrix assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CLASP1 →	-0.154	-1.202	<.001	.001	2	11
CNS	TGFB1 →	-0.413	-1.035	.001	.004	3	8
BLOOD_Myeloma	SRPK2 →	+0.337	+1.295	.003	<.001	3	5
BREAST	SOX9 →	-0.178	-1.220	<.001	<.001	3	5
BREAST	PHLDB2 →	-0.270	-0.823	.002	.001	3	4
LARGE_INTESTINE	WIPI1 →	-0.126	-1.101	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLASP1 by Positive regulation of extracellular matrix assembly activity — OESOPHAGUS

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