Positive regulation of extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANGRF, ORMDL2, and SCN2A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extracellular matrix assembly activity versus RANGRF in LUNG_NSCLC_LUAD (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RANGRF →	+2.002	+0.437	.002	.002	3	2
LUNG_NSCLC_LUAD	ORMDL2 →	+1.073	+0.353	<.001	<.001	3	2
LUNG_NSCLC_LUAD	SCN2A →	-0.256	-0.351	.008	<.001	3	2
LUNG_NSCLC_LUAD	PRPSAP2 →	+1.736	+0.353	.001	<.001	3	2
LUNG_NSCLC_LUAD	CDA →	+4.615	+0.393	.004	.009	2	3
LUNG_NSCLC_LUAD	C1orf122 →	+1.292	+0.335	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901203 vs RANGRF — LUNG_NSCLC_LUAD

Explore this scatter interactively →