Regulation of extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Regulation of extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPE, PPIE, and L2HGDH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNRPE grouped by Regulation of extracellular matrix assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SNRPE →	+0.724	+1.019	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	PPIE →	+1.113	+1.554	<.001	<.001	3	5
BLOOD_Leukemia	L2HGDH →	+1.014	+1.332	<.001	<.001	3	5
BLOOD_Leukemia	RAD51C →	+0.760	+1.320	.002	<.001	3	5
SOFT_TISSUE	MCM8 →	+0.926	+1.455	.004	.001	3	5
UPPER_AERODIGESTIVE_TRACT	NUSAP1 →	+1.851	+1.576	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNRPE by Regulation of extracellular matrix assembly activity — SOFT_TISSUE

Explore this box plot interactively →