Positive regulation of ERBB signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of ERBB signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3D19, CD248, and AFAP1L2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ERBB signaling pathway activity versus SH3D19 in BRCA (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH3D19 →	+0.500	+0.043	<.001	<.001	3	7
LSCC	CD248 →	+0.405	+0.053	<.001	<.001	3	6
LSCC	AFAP1L2 →	+0.772	+0.079	<.001	<.001	3	6
BRCA	FILIP1L_S1035 →	+0.536	+0.045	<.001	<.001	3	6
LSCC	MYH9_S1943 →	+0.467	+0.056	<.001	<.001	3	6
CCRCC	PCOLCE →	+0.798	+0.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901186 vs SH3D19 — BRCA

Explore this scatter interactively →