Positive regulation of ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7, FMNL3, and AGR2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ERBB signaling pathway activity versus MAP7 in OESOPHAGUS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MAP7 →	+1.541	+0.307	.008	.001	3	7
PANCREAS	FMNL3 →	-1.325	-0.282	<.001	<.001	3	6
LUNG_NSCLC_LUAD	AGR2 →	+4.445	+0.304	<.001	.002	3	6
BREAST	MRAS →	-2.585	-0.342	<.001	<.001	3	6
BREAST	PPP1R14D →	+0.641	+0.298	.001	.001	3	6
BREAST	TJP3 →	+3.299	+0.319	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901186 vs MAP7 — OESOPHAGUS

Explore this scatter interactively →