Negative regulation of ERBB signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERO1A, ALOX5AP, and RAB39B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERBB signaling pathway activity versus ERO1A in PDAC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ERO1A →	+0.593	+0.184	<.001	<.001	3	6
LSCC	ALOX5AP →	+0.839	+0.274	<.001	<.001	3	6
HNSC	RAB39B →	-0.734	-0.211	<.001	<.001	3	5
LSCC	IFNGR2 →	+0.392	+0.218	<.001	.008	3	5
BRCA	S100A10 →	+0.764	+0.124	.008	.005	2	6
LUAD	TNFRSF12A →	+0.461	+0.149	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901185 vs ERO1A — PDAC

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