Negative regulation of ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIK, ANKRD22, and STAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BIK grouped by Negative regulation of ERBB signaling pathway-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BIK →	+1.163	+0.199	.008	.002	3	3
UPPER_AERODIGESTIVE_TRACT	ANKRD22 →	+1.958	+0.232	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	STAP2 →	+0.966	+0.269	.006	<.001	3	3
LUNG_NSCLC_LUSC	SHF →	-2.174	-0.369	<.001	.002	3	3
LUNG_NSCLC_LUSC	RAB6B →	-2.126	-0.299	.007	.006	2	4
LIVER	FUT2 →	+0.890	+0.370	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BIK by Negative regulation of ERBB signaling pathway activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →