Negative regulation of ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERBB signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR5, AHI1, and ZNF92, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLR5 grouped by Negative regulation of ERBB signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TLR5 →	+0.231	+0.089	.004	.003	3	5
BONE	AHI1 →	-0.567	-0.174	.004	<.001	3	4
BREAST	ZNF92 →	+0.148	+0.084	<.001	.001	3	4
LUNG_SCLC	LETM1 →	-0.205	-0.078	.004	<.001	3	4
BONE	PLRG1 →	-0.522	-0.160	.008	.001	3	4
LUNG_NSCLC_LUSC	ST6GALNAC6 →	+0.262	+0.086	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLR5 by Negative regulation of ERBB signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →