Negative regulation of ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHA2, MAFF, and MVP, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERBB signaling pathway activity versus EPHA2 in BONE (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	EPHA2 →	+2.372	+0.113	<.001	.004	3	12
BONE	MAFF →	+2.017	+0.142	<.001	<.001	3	11
BONE	MVP →	+2.992	+0.116	<.001	<.001	3	11
STOMACH	PLEKHN1 →	+1.484	+0.106	.003	.006	3	11
BONE	PHLDA1 →	+3.336	+0.132	<.001	<.001	3	11
LUNG_NSCLC_LUAD	SMAD3 →	+1.727	+0.077	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901185 vs EPHA2 — BONE

Explore this scatter interactively →