Negative regulation of ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NADK, ATXN10, and PGGT1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERBB signaling pathway activity versus NADK in LARGE_INTESTINE (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NADK →	-0.487	-0.190	.008	.001	3	4
BREAST	ATXN10 →	+0.497	+0.483	.008	.004	2	5
URINARY_TRACT	PGGT1B →	-0.424	-0.211	.007	.006	2	4
UPPER_AERODIGESTIVE_TRACT	STMP1 →	-0.805	-0.369	.002	.001	3	3
BLOOD_Lymphoma	PTAFR →	+1.975	+0.163	.001	.004	3	3
LUNG_NSCLC_LUAD	NAGK →	+0.859	+0.224	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901185 vs NADK — LARGE_INTESTINE

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