Neural crest cell migration involved in autonomic nervous system development

Across TCGA patient cohorts, RNA activity of the Neural crest cell migration involved in autonomic nervous system development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRP2, LGALS1_S30, and PPP1R18_S224, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest cell migration involved in autonomic nervous system development activity versus NRP2 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NRP2 →	+0.649	+0.117	.001	<.001	3	10
LSCC	LGALS1_S30 →	+0.819	+0.100	<.001	<.001	3	9
BRCA	PPP1R18_S224 →	+0.660	+0.085	<.001	<.001	3	9
LSCC	PXDN →	+0.479	+0.097	.001	.002	3	9
GBM	RCN3 →	+0.611	+0.090	<.001	<.001	3	8
GBM	SULF1 →	+0.840	+0.067	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901166 vs NRP2 — OV

Explore this scatter interactively →