Neural crest cell migration involved in autonomic nervous system development

Across TCGA cell cohorts, RNA activity of the Neural crest cell migration involved in autonomic nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F3, SMAD3, and TIMM10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest cell migration involved in autonomic nervous system development activity versus F3 in LIVER (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	F3 →	+3.067	+0.345	.007	.009	3	3
STOMACH	SMAD3 →	+2.048	+2.006	.007	.006	2	4
CNS	TIMM10 →	-0.639	-0.860	.006	.002	3	2
PANCREAS	RBMX →	-0.402	-1.624	.002	.006	3	2
CNS	LMBRD1 →	+0.562	+0.818	.003	.004	3	2
CNS	PFAS →	-0.657	-1.109	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901166 vs F3 — LIVER

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