Positive regulation of trophoblast cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of trophoblast cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMF1, GSPT1, and ZMYM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of trophoblast cell migration activity versus TMF1 in BRCA (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMF1 →	-0.268	-0.043	<.001	<.001	3	6
COAD	GSPT1 →	-0.210	-0.042	.002	.007	3	6
LSCC	ZMYM2 →	+0.312	+0.059	<.001	<.001	3	6
CCRCC	LAMA4 →	+0.511	+0.075	<.001	<.001	3	6
HNSC	LAMC1 →	+0.440	+0.073	.001	.004	3	6
CCRCC	NID2 →	+0.360	+0.077	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901165 vs TMF1 — BRCA

Explore this scatter interactively →