Positive regulation of trophoblast cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of trophoblast cell migration pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNE4, SLC38A9, and RNU6-1077P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of trophoblast cell migration activity versus KCNE4 in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KCNE4 →	+0.723	+0.769	.003	.002	3	3
OV	SLC38A9 →	-0.462	-0.486	<.001	.005	3	3
COAD	RNU6-1077P →	-0.307	-1.034	.005	.001	3	3
COAD	TRBV15 →	-0.388	-0.554	.007	.007	2	4
LUAD	NOL3 →	+0.323	+0.398	.007	.003	3	3
LUAD	DHRS9 →	-0.444	-0.400	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901165 vs KCNE4 — CCRCC

Explore this scatter interactively →