Negative regulation of trophoblast cell migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of trophoblast cell migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02716, IQGAP3, and GJA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of trophoblast cell migration activity versus LINC02716 in GBM (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LINC02716 →	+0.871	+0.406	<.001	<.001	3	5
UCEC	IQGAP3 →	-1.016	-0.744	.002	.002	3	5
OV	GJA1 →	+1.800	+0.515	<.001	.004	3	4
UCEC	GASK1B →	+1.090	+0.655	.001	.004	3	4
OV	DACT3 →	+0.631	+0.399	.002	.005	3	4
HNSC	CCL8 →	-1.599	-0.310	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901164 vs LINC02716 — GBM

Explore this scatter interactively →