Negative regulation of trophoblast cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of trophoblast cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDZK1IP1, NUP188, and NFKBIZ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDZK1IP1 grouped by Negative regulation of trophoblast cell migration-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PDZK1IP1 →	+2.295	+2.222	.005	.003	3	4
STOMACH	NUP188 →	-0.567	-1.118	.005	.001	3	4
OESOPHAGUS	NFKBIZ →	+1.857	+1.378	<.001	.003	3	4
LARGE_INTESTINE	SPTAN1 →	+0.682	+0.930	<.001	.003	3	4
CNS	LRP10 →	+0.964	+0.877	<.001	.004	3	4
PANCREAS	APOL1 →	+3.076	+1.356	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDZK1IP1 by Negative regulation of trophoblast cell migration activity — LIVER

Explore this box plot interactively →