Negative regulation of trophoblast cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of trophoblast cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL1, PRKACA, and PRIM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYBL1 grouped by Negative regulation of trophoblast cell migration-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYBL1 →	+0.211	+0.161	.001	.002	3	5
SOFT_TISSUE	PRKACA →	+0.199	+0.252	<.001	<.001	3	4
BLOOD_Leukemia	PRIM2 →	-0.277	-0.182	.003	<.001	3	4
BLOOD_Leukemia	OVCH1 →	+0.287	+0.176	.001	.003	3	4
LUNG_SCLC	SMIM14 →	+0.270	+0.200	.007	.003	3	4
LUNG_SCLC	MCC →	-0.316	-0.308	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYBL1 by Negative regulation of trophoblast cell migration activity — PANCREAS

Explore this box plot interactively →