Negative regulation of trophoblast cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of trophoblast cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZXDC, TCF20, and CDPF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of trophoblast cell migration activity versus ZXDC in BONE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZXDC →	+1.027	+0.285	.004	.001	3	5
CNS	TCF20 →	+0.548	+0.145	.001	.003	3	4
BONE	CDPF1 →	+0.713	+0.285	.001	.001	3	4
BONE	TEX52 →	+0.782	+0.317	.008	.004	3	4
SOFT_TISSUE	RTN4R →	+3.132	+0.217	<.001	<.001	3	4
BREAST	C1orf35 →	+0.958	+0.280	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901164 vs ZXDC — BONE

Explore this scatter interactively →