Primary amino compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Primary amino compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GJB1_S233, RCOR3_S156, and CYB5B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary amino compound biosynthetic process activity versus GJB1_S233 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GJB1_S233 →	+1.361	+0.055	.006	.006	3	5
HNSC	RCOR3_S156 →	+0.797	+0.089	.003	.002	3	4
LUAD	CYB5B →	+0.247	+0.052	<.001	.003	3	4
COAD	ZKSCAN1 →	+0.392	+0.068	.001	.005	3	4
UCEC	COL7A1 →	-0.683	-0.117	<.001	.001	3	4
UCEC	MYO9B →	-0.271	-0.117	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901162 vs GJB1_S233 — LUAD

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