Primary amino compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Primary amino compound biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, ACLY, and CSH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Primary amino compound biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TLN1 →	-0.686	-1.845	.001	<.001	3	5
LIVER	ACLY →	+0.401	+1.614	.002	.004	3	4
STOMACH	CSH1 →	-0.237	-1.399	.003	.004	3	4
KIDNEY	ZDHHC21 →	+0.258	+1.231	.007	.003	3	4
STOMACH	PIP5K1P1 →	-0.304	-1.578	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	NIPAL2 →	+0.121	+0.195	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Primary amino compound biosynthetic process activity — LIVER

Explore this box plot interactively →