Primary amino compound metabolic process

pathway activity — cross-omics
GO:1901160Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Primary amino compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC43A3, DCBLD2, and RN7SKP64, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSLC43A3 →-0.651-0.553<.001.00233
GBMDCBLD2 →-0.732-0.635.001<.00133
HNSCRN7SKP64 →-0.709-0.651.001<.00133
PDACPPP1R18 →-0.350-0.508.001.00833
PDACCYTOR →-0.347-0.620.002.00133
PDACDNAJB6P3 →-0.233-0.592.001.00333
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration