Insulin metabolic process

Across TCGA patient cohorts, RNA activity of the Insulin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUCB2, FNDC3A, and TIPIN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin metabolic process activity versus NUCB2 in LUAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NUCB2 →	+0.511	+0.093	<.001	<.001	3	8
LSCC	FNDC3A →	+0.348	+0.062	<.001	<.001	3	7
OV	TIPIN →	-1.414	-0.061	<.001	<.001	3	6
GBM	AGA →	+0.557	+0.055	.001	<.001	3	6
BRCA	NASP →	-0.553	-0.058	<.001	<.001	3	6
GBM	SIL1 →	+0.329	+0.037	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901142 vs NUCB2 — LUAD

Explore this scatter interactively →