Insulin metabolic process

Across TCGA patient cohorts, RNA activity of the Insulin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP14, SPHK1, and HMGN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin metabolic process activity versus MMP14 in GBM (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP14 →	+1.029	+0.252	<.001	.001	3	5
BRCA	SPHK1 →	+0.882	+0.173	.002	.007	3	5
LSCC	HMGN3 →	-0.416	-0.188	.001	.002	3	4
GBM	GYS1 →	+0.447	+0.209	<.001	.001	3	4
GBM	PLAUR →	+1.072	+0.218	<.001	.005	3	4
GBM	TREM1 →	+1.502	+0.271	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901142 vs MMP14 — GBM

Explore this scatter interactively →