Insulin metabolic process

Across TCGA cell cohorts, RNA activity of the Insulin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSD, NABP1, and KRT19, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin metabolic process activity versus CTSD in BLOOD_Leukemia (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CTSD →	+1.686	+0.325	<.001	<.001	3	11
BLOOD_Leukemia	NABP1 →	+2.002	+0.284	<.001	<.001	3	6
BREAST	KRT19 →	+4.612	+0.240	.002	.001	3	6
OESOPHAGUS	UBQLNL →	+0.220	+0.203	.005	.006	3	5
PANCREAS	NEU3 →	-0.660	-0.172	.002	.004	3	5
BREAST	PTTG1 →	-1.089	-0.191	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901142 vs CTSD — BLOOD_Leukemia

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