Carbohydrate derivative catabolic process

Across TCGA patient cohorts, RNA activity of the Carbohydrate derivative catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, PIP4K2A, and STAB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate derivative catabolic process activity versus AIF1 in GBM (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AIF1 →	+0.603	+0.029	<.001	<.001	3	8
GBM	PIP4K2A →	+0.690	+0.046	<.001	<.001	3	8
GBM	STAB1 →	+0.438	+0.023	<.001	.001	3	7
BRCA	CLIC2 →	+0.376	+0.020	<.001	<.001	3	7
BRCA	GNB4 →	+0.351	+0.025	<.001	<.001	3	7
GBM	NCKAP1L →	+0.504	+0.033	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901136 vs AIF1 — GBM

Explore this scatter interactively →