Carbohydrate derivative catabolic process

Across TCGA cell cohorts, RNA activity of the Carbohydrate derivative catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB34, PHF10, and ZSCAN9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB34 grouped by Carbohydrate derivative catabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZBTB34 →	-0.868	-0.193	<.001	<.001	3	4
KIDNEY	PHF10 →	+1.227	+1.097	.001	.004	3	3
OVARY	ZSCAN9 →	-0.674	-1.078	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	POR →	-0.823	-0.140	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SLC35D2 →	-0.657	-0.146	.003	.001	3	3
UPPER_AERODIGESTIVE_TRACT	SURF1 →	-1.530	-0.208	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB34 by Carbohydrate derivative catabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →