Carbohydrate derivative catabolic process

Across TCGA cell cohorts, RNA activity of the Carbohydrate derivative catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA3, LAMC2, and DSC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate derivative catabolic process activity versus LAMA3 in URINARY_TRACT (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LAMA3 →	-3.746	-0.225	.001	.003	3	7
KIDNEY	LAMC2 →	-5.278	-0.232	<.001	.001	3	7
OVARY	DSC2 →	-2.125	-0.341	<.001	<.001	3	6
LUNG_NSCLC_LUSC	CDH3 →	-5.245	-0.310	<.001	.001	3	6
LUNG_SCLC	LAMA5 →	-2.056	-0.248	<.001	<.001	3	6
LUNG_NSCLC_LUAD	CST6 →	-2.513	-0.120	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901136 vs LAMA3 — URINARY_TRACT

Explore this scatter interactively →