Positive regulation of autophagosome maturation

Across TCGA patient cohorts, RNA activity of the Positive regulation of autophagosome maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3_S97, XPO5, and BYSL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of autophagosome maturation activity versus SASH3_S97 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SASH3_S97 →	+0.634	+0.108	<.001	<.001	3	7
LSCC	XPO5 →	-0.565	-0.073	<.001	<.001	3	7
BRCA	BYSL →	-0.418	-0.047	<.001	<.001	3	7
LSCC	CDK1 →	-0.835	-0.129	<.001	<.001	3	7
LSCC	EIF3E_S399 →	-0.734	-0.102	<.001	<.001	3	6
LUAD	RACGAP1_T580 →	-1.543	-0.122	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901098 vs SASH3_S97 — GBM

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