Positive regulation of autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM122B, GRIP1, and XPC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM122B grouped by Positive regulation of autophagosome maturation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM122B →	-0.911	-1.248	.001	<.001	3	4
SOFT_TISSUE	GRIP1 →	-2.252	-1.145	.007	.003	2	5
LIVER	XPC →	-0.586	-1.424	.004	.001	3	4
CNS	PARD3B →	-0.688	-1.052	.008	.004	2	5
CNS	CPT2 →	-0.670	-1.130	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TSC22D1 →	-1.326	-1.702	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM122B by Positive regulation of autophagosome maturation activity — OESOPHAGUS

Explore this box plot interactively →