Positive regulation of autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOM1, YARS2, and SOD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of autophagosome maturation activity versus TOM1 in SKIN (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TOM1 →	+1.293	+1.404	.002	.002	3	5
LUNG_NSCLC_LUAD	YARS2 →	-1.288	-1.224	.002	.004	3	5
BREAST	SOD1 →	+0.654	+1.115	<.001	<.001	3	4
BREAST	RIC8B →	-0.783	-1.071	.004	.002	3	4
LARGE_INTESTINE	MDM1 →	-0.913	-0.952	<.001	.007	3	3
CNS	SLC25A36 →	+0.678	+0.840	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901098 vs TOM1 — SKIN

Explore this scatter interactively →