Negative regulation of autophagosome maturation

Across TCGA patient cohorts, RNA activity of the Negative regulation of autophagosome maturation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMPK2, AGAP1_T836, and GOLM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagosome maturation activity versus CMPK2 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CMPK2 →	+0.499	+0.046	.002	.003	3	5
PDAC	AGAP1_T836 →	-0.618	-0.032	.007	.002	3	5
LUAD	GOLM1 →	-0.833	-0.077	<.001	<.001	3	5
LSCC	RUBCN →	+0.205	+0.059	<.001	<.001	3	5
LSCC	CTNND1_T916 →	-0.672	-0.041	.001	.002	3	5
LUAD	PAK2 →	+0.215	+0.049	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901097 vs CMPK2 — HNSC

Explore this scatter interactively →