Negative regulation of autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Negative regulation of autophagosome maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBQLN4, RUBCN, and PHF23, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBQLN4 grouped by Negative regulation of autophagosome maturation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UBQLN4 →	-0.235	-0.227	.002	.001	3	10
CNS	RUBCN →	-0.225	-0.579	.001	.007	3	8
CNS	PHF23 →	-0.254	-0.706	.001	.009	3	8
STOMACH	CLEC16A →	-0.221	-1.336	<.001	.005	3	7
SOFT_TISSUE	AGPAT5 →	-0.325	-0.932	<.001	.003	3	4
BLOOD_Leukemia	FZD8 →	-0.219	-1.001	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBQLN4 by Negative regulation of autophagosome maturation activity — PANCREAS

Explore this box plot interactively →