Negative regulation of autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Negative regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACP2, PCIF1, and MT-CYB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACP2 grouped by Negative regulation of autophagosome maturation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACP2 →	+0.721	+0.905	<.001	.001	2	5
SOFT_TISSUE	PCIF1 →	+0.538	+1.375	.002	.002	3	3
SOFT_TISSUE	MT-CYB →	-1.070	-1.284	.002	.004	3	3
SOFT_TISSUE	ITGA1 →	+2.595	+1.350	.003	.003	3	3
BLOOD_Leukemia	TSPAN5 →	+1.400	+0.782	.007	.001	3	3
KIDNEY	SDR9C7 →	+0.077	+1.346	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACP2 by Negative regulation of autophagosome maturation activity — BLOOD_Leukemia

Explore this box plot interactively →