Negative regulation of autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Negative regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUBCN, CLEC16A, and KATNIP, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagosome maturation activity versus RUBCN in KIDNEY (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RUBCN →	+1.130	+0.112	<.001	<.001	3	20
BONE	CLEC16A →	+0.960	+0.146	<.001	<.001	3	19
URINARY_TRACT	KATNIP →	+1.193	+0.087	<.001	.006	3	19
SOFT_TISSUE	SLX4 →	+0.887	+0.093	<.001	<.001	3	16
PANCREAS	SMG1 →	+1.169	+0.080	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	ZNF646 →	+0.955	+0.118	.002	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901097 vs RUBCN — KIDNEY

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