Regulation of autophagosome maturation

Across TCGA patient cohorts, RNA activity of the Regulation of autophagosome maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKAR2B, SAMHD1, and UBLCP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of autophagosome maturation activity versus PRKAR2B in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRKAR2B →	+0.556	+0.059	<.001	<.001	3	6
LSCC	SAMHD1 →	+0.331	+0.067	<.001	<.001	3	5
CCRCC	UBLCP1 →	+0.138	+0.037	<.001	.001	3	5
GBM	EIF6 →	-0.260	-0.067	<.001	<.001	3	5
LSCC	EVL_S246 →	+0.594	+0.051	<.001	<.001	3	5
LSCC	INPP4A →	+0.175	+0.046	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901096 vs PRKAR2B — GBM

Explore this scatter interactively →