Regulation of autophagosome maturation

Across TCGA patient cohorts, RNA activity of the Regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CATSPER2, NDUFAF5, and KIAA0895L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of autophagosome maturation activity versus CATSPER2 in HNSC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CATSPER2 →	-0.434	-0.495	.007	.006	3	6
GBM	NDUFAF5 →	-0.267	-0.534	.002	.002	3	6
BRCA	KIAA0895L →	-0.535	-0.577	.007	.006	3	5
GBM	DHX57 →	-0.347	-0.704	<.001	<.001	3	5
GBM	POLR3F →	-0.242	-0.558	.008	.002	3	5
BRCA	PABPN1 →	-0.423	-0.508	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901096 vs CATSPER2 — HNSC

Explore this scatter interactively →