Regulation of autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP6, CD55, and MACROH2A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP6 grouped by Regulation of autophagosome maturation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GTPBP6 →	+1.084	+0.309	<.001	.001	3	4
SOFT_TISSUE	CD55 →	+2.904	+1.177	.001	.002	2	5
LARGE_INTESTINE	MACROH2A1 →	-0.423	-0.650	.003	.003	3	3
LARGE_INTESTINE	TEKT3 →	+0.345	+1.222	.001	<.001	3	3
LUNG_NSCLC_LUAD	SYNE3 →	+0.707	+0.803	.005	.001	3	3
BONE	ZMAT1 →	-2.705	-1.400	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP6 by Regulation of autophagosome maturation activity — URINARY_TRACT

Explore this box plot interactively →