Regulation of autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOM1, ARL8A, and RRBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of autophagosome maturation activity versus TOM1 in LUNG_NSCLC_LUAD (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TOM1 →	+0.670	+0.406	<.001	.002	3	6
SKIN	ARL8A →	+0.930	+0.871	.002	.002	3	4
LIVER	RRBP1 →	+1.135	+0.352	.001	.006	2	5
LUNG_NSCLC_LUAD	ATP6V1A →	+0.721	+0.526	.005	.008	3	4
LUNG_NSCLC_LUSC	KDELR2 →	+0.984	+0.653	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CFAP45 →	+0.975	+0.835	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901096 vs TOM1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →