Negative regulation of relaxation of muscle

Across TCGA cell cohorts, RNA activity of the Negative regulation of relaxation of muscle pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM17, FAM78A, and RPS17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM17 grouped by Negative regulation of relaxation of muscle-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RBM17 →	+0.534	+0.810	.008	.004	3	5
BLOOD_Myeloma	FAM78A →	-2.529	-1.400	.003	.005	3	5
LARGE_INTESTINE	RPS17 →	-0.639	-1.207	.002	.002	3	5
STOMACH	CENPE →	-0.752	-0.885	.009	.006	3	4
LUNG_SCLC	RPL32 →	-0.964	-0.933	.002	.008	3	4
LUNG_SCLC	TRA2A →	+0.950	+1.031	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM17 by Negative regulation of relaxation of muscle activity — BREAST

Explore this box plot interactively →