Regulation of relaxation of muscle

Across TCGA patient cohorts, RNA activity of the Regulation of relaxation of muscle pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE4D, CAMK2D, and PDE7B, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of relaxation of muscle activity versus PDE4D in SARC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	PDE4D →	+1.713	+0.100	<.001	<.001	3	19
UCS	CAMK2D →	+1.093	+0.118	.002	<.001	3	18
THCA	PDE7B →	+1.218	+0.057	<.001	<.001	3	18
SKCM	PDE4B →	+1.169	+0.063	<.001	<.001	3	18
TGCT	HCFC2 →	+0.663	+0.065	<.001	<.001	3	17
KIRC	TMEM30A →	+0.426	+0.038	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901077 vs PDE4D — SARC

Explore this scatter interactively →