Regulation of relaxation of muscle

Across TCGA patient cohorts, RNA activity of the Regulation of relaxation of muscle pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSE1L, PPP1R18_S368, and MYLK_S1617, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of relaxation of muscle activity versus CSE1L in UCEC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSE1L →	-0.303	-0.107	<.001	.002	3	7
LSCC	PPP1R18_S368 →	+0.484	+0.110	<.001	<.001	3	7
OV	MYLK_S1617 →	+1.085	+0.153	.001	.002	3	6
LSCC	AATF →	-0.315	-0.118	<.001	<.001	3	6
COAD	STAU1 →	-0.236	-0.052	.008	.003	2	7
LSCC	WDR36 →	-0.256	-0.128	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901077 vs CSE1L — UCEC

Explore this scatter interactively →