Regulation of relaxation of muscle

Across TCGA cell cohorts, RNA activity of the Regulation of relaxation of muscle pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRI, PIK3CA, and ACP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of relaxation of muscle activity versus SRI in SKIN (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SRI →	+0.827	+0.291	<.001	<.001	3	5
BLOOD_Leukemia	PIK3CA →	-0.736	-0.267	.003	.003	3	4
BLOOD_Leukemia	ACP6 →	-1.439	-0.280	.001	.001	3	4
SKIN	MOSPD3 →	+0.697	+0.248	.003	.001	3	4
SKIN	OS9 →	+0.984	+0.207	<.001	<.001	3	4
SKIN	CAMK2D →	+1.140	+0.240	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901077 vs SRI — SKIN

Explore this scatter interactively →