Glucosamine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Glucosamine-containing compound catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSRP1, GTF3C3, and GTF3C4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucosamine-containing compound catabolic process activity versus SSRP1 in LSCC (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SSRP1 →	-0.500	-0.074	<.001	<.001	3	7
LSCC	GTF3C3 →	-0.331	-0.065	<.001	<.001	3	7
LSCC	GTF3C4 →	-0.306	-0.059	.008	.001	3	7
LSCC	SASH3 →	+0.327	+0.046	<.001	<.001	3	6
LSCC	ATAD2 →	-0.436	-0.055	.009	.002	3	6
LUAD	ATAD2_S342 →	-1.291	-0.050	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901072 vs SSRP1 — LSCC

Explore this scatter interactively →