Glucosamine-containing compound catabolic process

Across TCGA patient cohorts, RNA activity of the Glucosamine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRG3, FCGR3B, and CSF3R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucosamine-containing compound catabolic process activity versus ADGRG3 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRG3 →	+0.753	+0.148	.002	.001	3	9
LSCC	FCGR3B →	+1.315	+0.129	<.001	.001	3	8
HNSC	CSF3R →	+1.025	+0.184	<.001	<.001	3	7
GBM	PLAUR →	+1.172	+0.213	<.001	<.001	3	7
BRCA	BCL2A1 →	+1.512	+0.214	.001	<.001	3	7
UCEC	ITGAX →	+0.805	+0.197	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901072 vs ADGRG3 — LSCC

Explore this scatter interactively →