Glucosamine-containing compound catabolic process

Across TCGA cell cohorts, RNA activity of the Glucosamine-containing compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGK, ELK3, and DTWD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIGK grouped by Glucosamine-containing compound catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PIGK →	-0.967	-0.583	.002	.006	3	5
BLOOD_Leukemia	ELK3 →	-1.135	-1.040	.007	.006	3	4
LUNG_NSCLC_LUSC	DTWD1 →	-0.477	-0.907	.003	.006	3	3
LUNG_NSCLC_LUSC	PFDN5 →	-0.536	-0.891	.001	.007	3	3
BLOOD_Leukemia	ERLIN1 →	-1.085	-0.990	.009	.003	3	3
BLOOD_Leukemia	SEC22A →	-0.537	-1.149	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIGK by Glucosamine-containing compound catabolic process activity — LUNG_SCLC

Explore this box plot interactively →