Glucosamine-containing compound metabolic process

pathway activity — cross-omics
GO:1901071Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glucosamine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL8, LILRB3, and CD300A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCXCL8 →+1.506+0.133<.001<.00137
GBMLILRB3 →+1.020+0.154<.001<.00136
UCECCD300A →+0.920+0.200.001.00236
GBMCSF3R →+0.636+0.136.006<.00135
UCECCLEC4D →+0.648+0.200<.001<.00135
GBMFPR2 →+0.892+0.144<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration