Regulation of response to reactive oxygen species

Across TCGA patient cohorts, RNA activity of the Regulation of response to reactive oxygen species pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMOD1, QKI, and RIN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to reactive oxygen species activity versus LMOD1 in BRCA (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LMOD1 →	+0.680	+0.066	<.001	<.001	3	8
COAD	QKI →	+0.324	+0.059	<.001	<.001	3	7
OV	RIN3 →	+0.371	+0.061	<.001	<.001	3	6
LSCC	STAB1 →	+0.310	+0.066	<.001	<.001	3	6
COAD	AZGP1 →	+0.918	+0.043	<.001	.001	3	6
COAD	ACTN1 →	+0.386	+0.053	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901031 vs LMOD1 — BRCA

Explore this scatter interactively →