Regulation of response to reactive oxygen species

Across TCGA patient cohorts, RNA activity of the Regulation of response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASQ1, ZNF549, and PCP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to reactive oxygen species activity versus CASQ1 in GBM (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CASQ1 →	+0.636	+0.100	<.001	.007	3	4
UCEC	ZNF549 →	+0.398	+0.746	.002	.001	3	3
COAD	PCP4 →	+1.275	+0.122	.002	.002	3	3
UCEC	C1QTNF9 →	+0.357	+0.642	.009	<.001	3	3
COAD	PGM5P4-AS1 →	+0.059	+0.142	.008	.004	3	3
GBM	SLC2A4 →	+0.434	+0.162	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901031 vs CASQ1 — GBM

Explore this scatter interactively →