Regulation of response to reactive oxygen species

Across TCGA cell cohorts, RNA activity of the Regulation of response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENR, RBM7, and ZDHHC17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENR grouped by Regulation of response to reactive oxygen species-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DENR →	-0.671	-1.635	.003	<.001	3	4
KIDNEY	RBM7 →	-0.625	-1.344	.007	.001	3	4
LUNG_NSCLC_LUAD	ZDHHC17 →	-0.526	-0.770	.004	.005	3	4
LUNG_NSCLC_LUAD	FTL →	+1.200	+0.638	<.001	.004	3	4
SKIN	ZNF81 →	-0.622	-1.096	<.001	.001	3	4
LUNG_NSCLC_LUSC	TSPAN7 →	+3.393	+0.897	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENR by Regulation of response to reactive oxygen species activity — KIDNEY

Explore this box plot interactively →