Regulation of response to reactive oxygen species

Across TCGA cell cohorts, RNA activity of the Regulation of response to reactive oxygen species pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC6, USP7, and PITPNC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC6 grouped by Regulation of response to reactive oxygen species-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC6 →	-0.295	-0.186	.005	.006	3	6
STOMACH	USP7 →	+0.519	+0.140	<.001	<.001	3	5
BLOOD_Leukemia	PITPNC1 →	-0.350	-0.207	<.001	<.001	3	5
BONE	PPM1D →	+0.328	+0.167	.003	.003	3	5
STOMACH	PRKCSH →	-0.153	-0.176	.001	<.001	3	4
BLOOD_Leukemia	HSD17B7 →	-0.200	-0.132	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC6 by Regulation of response to reactive oxygen species activity — SOFT_TISSUE

Explore this box plot interactively →